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Anabolics effects, buy steroidsTestosterone circulates principally in bound form, mainly to sex hormone-binding globulin (SHBG) and albumin. It tightly binds to SHBG and is not biologically available, whereas the testosterone fraction associated with albumin is weakly bound and can dissociate to free, active testosterone (4). In young adult men, only about 2% of testosterone is in the free form, 30% is bound tightly to SHBG, and 68% is weakly bound to albumin (5). Although a testosterone determination is the threshold test in the evaluation of suspected male hypogonadism, the total testosterone concentration may be within the normal range in men with primary testicular disorders such as Klinefelter’s syndrome. Low production of testosterone and increased estradiol stimulate production of SHBG by the liver.
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